“Individuals who scored high for the resiliency trait on a personality questionnaire tended to be capable of more opioid release during social rejection, especially in the amygdala,” a region of the brain involved in emotional processing, Hsu says. “This suggests that opioid release in this structure during social rejection may be protective or adaptive.”
The more opioid release during social rejection in another brain area called the pregenual cingulate cortex, the less the participants reported being put in a bad mood by the news that they’d been snubbed.
The researchers also examined what happens when the participants were told that someone they’d expressed interest in had expressed interest in them – social acceptance. In this case, some brain regions also had more opioid release. “The opioid system is known to play a role in both reducing pain and promoting pleasure, and our study shows that it also does this in the social environment,” says Hsu...
“It is possible that those with depression or social anxiety are less capable of releasing opioids during times of social distress, and therefore do not recover as quickly or fully from a negative social experience. Similarly, these individuals may also have less opioid release during positive social interactions, and therefore may not gain as much from social support,” Hsu theorizes."
The rest of the article at U of MI Health: http://www.uofmhealth.org/news/archive/201310/opioid-social
Molecular Psychology Journal:http://www.nature.com/mp/journal/vaop/ncurrent/full/mp201396a.html